SAN DIEGO–Pandemic H1N1 is the primary influenza virus circulating this season in San Diego and across most of the nation, the County Health and Human Services Agency said.

Of 1,730 lab-confirmed influenza cases reported so far this season in San Diego, nearly 94 percent are influenza A. Influenza A has several subtypes, including Pandemic H1N1 and H3N2. During a typical year, the primary influenza virus is H3N2 or “seasonal” flu. This season, there are 10 cases of Pandemic H1N1 for every case of H3N2.

The Centers for Disease Control and Prevention (CDC) has reported that Pandemic H1N1 is the main influenza virus making Americans sick across the nation. Local and national flu reports show that adolescents and young to middle-aged adults are more affected than other age groups.

The CDC has investigated why H1N1 virus sickens more young people compared to children and older adults, who are typically hit hardest by other flu strains because of their weaker immune systems. Two factors seem to play a part: younger and middle-aged adults have not been exposed to the H1N1 virus as much as older adults, and these groups typically have the lowest vaccination rates in the nation.

In 2009, the CDC concluded that adults older than 60 years of age had a level of immunity that was not present in children and younger adults when the H1N1 pandemic hit that year. Further research has revealed that the 2009 Pandemic H1N1 virus has similar components to a previous H1N1 virus that was dominant during the 1950s and even earlier.

“Older people have some element of immunity to Pandemic H1N1 because they’ve had more exposure to these influenza viruses than younger groups,” said Sayone Thihalolipavan, M.D., M.P.H., County deputy public health officer.

The death last week of a 26-year-old reporter visiting San Diego from Washington, D.C. is under investigation as possibly due to Pandemic H1N1 complications. It is unknown whether the woman had underlying medical conditions and whether she had received a flu shot. One local resident is a confirmed H1N1 death: a 49-year-old male with underlying medical conditions and unknown vaccination status.

“The recently reported deaths are a reminder that, regardless of your age, the best protection against any known strain of flu is getting vaccinated,” Thihalolipavan said. “The current flu vaccine offers protection against Pandemic H1N1, influenza H3N2 and two B flu strains.”

The County Health and Human Services Agency publishes the weekly Influenza Watch report, which tracks key flu indicators and summarizes influenza surveillance in the region. All other indicators are at expected levels for this time of year.